Neural Cell Adhesion Molecule (NCAM) and Myoblast Fusion
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چکیده
منابع مشابه
Neural cell adhesion molecule (NCAM) and myoblast fusion.
Considerable evidence points to an involvement of neural cell adhesion molecule (NCAM) in myoblast fusion. Changes in the level of NCAM expression, isoform specificity, and localization in muscle cells and tissues correspond to key morphogenetic events during muscle differentiation and repair. Furthermore, anti-NCAM antibodies have been shown by others to reduce the rate of myoblast fusion, whe...
متن کاملExpression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.
A comparative study on the expression of the neural cell adhesion molecule (NCAM) in human neuroblastoma cell lines and tissues was undertaken. NCAMs are a family of closely related cell surface glycoproteins involved in cell-cell interactions. Using antibodies that recognise distinct epitopes on NCAM, their presence was shown in neuroblastoma, but these studies do not yield any information on ...
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We have used a transfection based approach to analyze the role of neural cell adhesion molecule (NCAM) in myogenesis at the stage of myoblast fusion to form multinucleate myotubes. Stable cell lines of myogenic C2 cells were isolated that express the transmembrane 140- or 180-kD NCAM isoforms or the glycosylphosphatidylinositol (GPI) linked isoforms of 120 or 125 kD. We found that expression of...
متن کاملChanges in neural cell adhesion molecule (NCAM) structure during vertebrate neural development.
Changes in carbohydrate and polypeptide form of the neural cell adhesion molecule (NCAM) have been documented during the development of central nervous system tissue in both chicken and frog. The carbohydrate variations reflect a high and low content of polysialic acid, and for the two vertebrates examined the expression of these forms is similar. At very early stages of neural development NCAM...
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The neural cell adhesion molecule (NCAM) may be as important in the heart as it is in the nervous system. NCAM is a cell surface glycoprotein which manifests great diversity in polypeptide isoform and glycosylation throughout cardiogenesis as well as neurogenesis. It is expressed on cardiac myocytes in the myocardium and on epicardial and endocardial cells as well as on the components that inne...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2000
ISSN: 0012-1606
DOI: 10.1006/dbio.2000.9654